Mido scored a late penalty on his Wigan debut to further dent Liverpool's Premier League title ambitions.
The Egypt striker struck the ball past Pepe Reina after Lucas Leiva had clumsily brought down Jason Koumas.
Yossi Benayoun had brilliantly put Liverpool ahead from a tight angle, while Fernando Torres hit the post.
But Emmerson Boyce headed wide for Wigan and Hugo Rodallega struck the Liverpool crossbar late on as Rafael Benitez's Reds slipped to third.
The result was rich reward for Wigan manager Steve Bruce's willingness to chase the game after the break.
The Egypt striker struck the ball past Pepe Reina after Lucas Leiva had clumsily brought down Jason Koumas.
Yossi Benayoun had brilliantly put Liverpool ahead from a tight angle, while Fernando Torres hit the post.
But Emmerson Boyce headed wide for Wigan and Hugo Rodallega struck the Liverpool crossbar late on as Rafael Benitez's Reds slipped to third.
The result was rich reward for Wigan manager Steve Bruce's willingness to chase the game after the break.
